Atomoxetine and methylphenidate are similarly effective at improving cognitive executive functions in children and adults with ADHD compared to controls. This meta-analysis found no significant differences in effect size between drugs.
Non-stimulant medication is nearly as effective as stimulant medication at improving executive function in children, adolescents, and adults with ADHD, according to a systematic review and meta-analysis published in May by Neuroscience & Biobehavioral Reviews.
Long-term use of stimulant and non-stimulant medications had a similar positive effect on cognition, compared to placebo, for people with ADHD. Although the treatment effect sizes varied slightly in magnitude, a meta-regression analysis found no significant differences in the overall impact on cognition between each type of ADHD drug.
Source: Additude
